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TSEN2 Antibody

Product Specifications

Background

This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

80746

Swiss Prot

Q8NCE0

Accession Number

Q8NCE0

Host

Rabbit

Reactivity

Human

Immunogen

This TSEN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human TSEN2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TSEN2

NCBI Official Name

TRNA-splicing endonuclease subunit Sen2

NCBI Organism

Homo sapiens

Background Reference 01

Weitzer, S., et al. Nature 447 (7141) :222-226 (2007)

Background Reference 02

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Background Reference 03

Ballif, B.A., et al. Mol. Cell Proteomics 3 (11) :1093-1101 (2004)

Background Reference 04

Paushkin, S.V., et al. Cell 117 (3) :311-321 (2004)

Other Product Names

TRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2, HsSen2, TSEN2, SEN2

Tested Applications

WB

Protein ID

50428914

Physical Properties

Liquid

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