KHDRBS3 Antibody

Product Specifications

Background

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression.

NCBI Gene ID

10656

Swiss Prot

O75525

Accession Number

O75525

Host

Rabbit

Reactivity

Human

Immunogen

This KHDRBS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human KHDRBS3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KHDRBS3

NCBI Official Name

KH domain-containing, RNA-binding, signal transduction-associated protein 3

NCBI Organism

Homo sapiens

Background Reference 01

Xin, X., et al. Genome Res. 19 (7) :1262-1269 (2009)

Background Reference 02

Lu, Y., et al. PLoS ONE (7), E6159 (2009) :

Background Reference 03

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Background Reference 04

Schymick, J.C., et al. Lancet Neurol 6 (4) :322-328 (2007)

Other Product Names

KH domain-containing, RNA-binding, signal transduction-associated protein 3, RNA-binding protein T-Star, Sam68-like mammalian protein 2, SLM-2, Sam68-like phosphotyrosine protein, KHDRBS3, SALP, SLM2