KIT Antibody

Product Specifications

Background

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor) . Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

3815

Swiss Prot

P10721

Accession Number

P10721

Host

Rabbit

Reactivity

Human

Immunogen

This KIT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 691-720 amino acids from the Central region of human KIT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

110 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KIT

NCBI Official Name

Mast/stem cell growth factor receptor Kit

NCBI Organism

Homo sapiens

Background Reference 01

Molderings, G.J., et al. Immunogenetics 62 (11-12), 721-727 (2010) :

Background Reference 02

Cheng, M., et al. Circ. Res. 107 (9) :1083-1093 (2010)

Background Reference 03

Chi, P., et al. Nature 467 (7317) :849-853 (2010)

Background Reference 04

Rossi, S., et al. Am. J. Surg. Pathol. 34 (10) :1480-1491 (2010)

Other Product Names

Mast/stem cell growth factor receptor Kit, SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD117, KIT, SCFR