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PMM2 Antibody

Product Specifications

Background

The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq].

NCBI Gene ID

5373

Swiss Prot

O15305

Accession Number

O15305

Host

Rabbit

Reactivity

Human

Immunogen

This PMM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the C-terminal region of human PMM2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Monkey, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PMM2

NCBI Official Name

Phosphomannomutase 2

NCBI Organism

Homo sapiens

Background Reference 01

Vega, A.I., et al. Hum. Mutat. 30 (5) :795-803 (2009)

Background Reference 02

Coman, D., et al. Am. J. Med. Genet.146 (3) :389-392 (2008)

Background Reference 03

Vermeer, S., et al. J. Neurol. 254 (10) :1356-1358 (2007)

Background Reference 04

Coman, D., et al.Clin Neurosci 14 (7) :668-672 (2007)

Other Product Names

Phosphomannomutase 2, PMM 2, PMM2

Tested Applications

WB

Physical Properties

Liquid

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