GCHFR Antibody

Product Specifications

Background

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

NCBI Gene ID

2644

Swiss Prot

P30047

Accession Number

P30047

Host

Rabbit

Reactivity

Human

Immunogen

This GCHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the C-terminal region of human GCHFR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

10 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GCHFR

NCBI Official Name

GTP cyclohydrolase 1 feedback regulatory protein

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) McHugh, P.C., et al. Pharmacogenomics J. (2010) In pressLi, L., et al. Circ. Res. 106 (2) :328-336 (2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009) Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8 (8) :753-757 (2009)