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PDLIM3 Antibody

Product Specifications

Background

The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. This gene is found near a region of chromosome 4 that has been implicated in facioscapulohumeral muscular dystrophy, but this gene does not appear to be involved in the disease. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

27295

Swiss Prot

Q53GG5

Accession Number

Q53GG5

Host

Rabbit

Reactivity

Human

Immunogen

This PDLIM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-355 amino acids from the C-terminal region of human PDLIM3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDLIM3

NCBI Official Name

PDZ and LIM domain protein 3

NCBI Organism

Homo sapiens

Background Reference 01

Hershberger, R.E., et al. Clin Transl Sci 1 (1) :21-26 (2008)

Background Reference 02

Keira, Y., et al. Neurosci. Res. 57 (4) :513-521 (2007)

Background Reference 03

Arola, A.M., et al. Mol. Genet. Metab. 90 (4) :435-440 (2007)

Background Reference 04

Klaavuniemi, T., et al. J. Biol. Chem. 279 (25) :26402-26410 (2004)

Other Product Names

PDZ and LIM domain protein 3, Actinin-associated LIM protein, Alpha-actinin-2-associated LIM protein, PDLIM3, ALP

Tested Applications

WB

Protein ID

74740479

Physical Properties

Liquid

Frequently Asked Questions

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