PCGF6 Antibody

Product Specifications

Background

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI Gene ID

84108

Swiss Prot

Q9BYE7

Accession Number

Q9BYE7

Host

Rabbit

Reactivity

Human

Immunogen

This PCGF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-217 amino acids from the Central region of human PCGF6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PCGF6

NCBI Official Name

Polycomb group RING finger protein 6

NCBI Organism

Homo sapiens

Background Reference 01

Lee, J.Y., et al. Cancer Res. 68 (11) :4201-4209 (2008)

Background Reference 02

Zhang, J., et al. J. Biol. Chem. 283 (12) :7464-7469 (2008)

Background Reference 03

Lee, M.G., et al. Cell 128 (5) :877-887 (2007)

Background Reference 04

Zhong, N., et al. Biochem. Biophys. Res. Commun. 338 (2) :855-861 (2005)

Other Product Names

Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134

Tested Applications

Protein ID

116242703

Physical Properties

Liquid

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