PCDHGB4 Antibody

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes.

This PCDHGB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-379 amino acids from the Central region of human PCDHGB4.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001) Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000) Yagi, T., et al. Genes Dev. 14 (10) :1169-1180 (2000) Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97 (7) :3124-3129 (2000) Wu, Q., et al. Cell 97 (6) :779-790 (1999)