P2RX3 Antibody

Product Specifications

Background

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

NCBI Gene ID

5024

Swiss Prot

P56373

Accession Number

P56373

Host

Rabbit

Reactivity

Human

Immunogen

This P2RX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-356 amino acids from the C-terminal region of human P2RX3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

44 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

P2RX3

NCBI Official Name

P2X purinoceptor 3

NCBI Organism

Homo sapiens

Background Reference 01

Allsopp, R.C., et al. J. Biol. Chem. 285 (43) :32770-32777 (2010)

Background Reference 02

Beneng, K., et al. IntOral Maxillofac Surg 39 (8) :815-819 (2010)

Background Reference 03

Nair, A., et al. Cell. Mol. Neurobiol. 30 (4) :505-509 (2010)

Background Reference 04

Jacques-Silva, M.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (14) :6465-6470 (2010)

Other Product Names

P2X purinoceptor 3, P2X3, ATP receptor, Purinergic receptor, P2RX3

Tested Applications

Protein ID

259016295

Physical Properties

Liquid

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