ITGA7 Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

NCBI Gene ID

3679

Swiss Prot

Q13683

Accession Number

Q13683

Host

Rabbit

Reactivity

Human

Immunogen

This ITGA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-257 amino acids from the N-terminal region of human ITGA7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

129 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ITGA7

NCBI Official Name

Integrin alpha-7

NCBI Organism

Homo sapiens

Background Reference 01

Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

Background Reference 02

Han, Y.C., et al. Cancer Res. 70 (11) :4375-4384 (2010)

Background Reference 03

Rooney, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (19) :7991-7996 (2009)

Background Reference 04

Liu, J., et al. J. Biol. Chem. 283 (51) :35668-35678 (2008)

Other Product Names

Integrin alpha-7, Integrin alpha-7 heavy chain, Integrin alpha-7 light chain, Integrin alpha-7 70 kDa form, ITGA7

Tested Applications

Protein ID

308153592

Physical Properties

Liquid

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