FRS2 Antibody

Product Specifications

Background

Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

NCBI Gene ID

10818

Swiss Prot

Q8WU20

Accession Number

Q8WU20

Host

Rabbit

Reactivity

Human

Immunogen

This FRS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human FRS2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FRS2

NCBI Official Name

Fibroblast growth factor receptor substrate 2

NCBI Organism

Homo sapiens

Background Reference 01

Zhou, W., et al. Cell Res. 19 (10) :1165-1177 (2009)

Background Reference 02

Cha, J.Y., et al. J. Biol. Chem. 284 (10) :6227-6240 (2009)

Background Reference 03

Li, M., et al. J. Dermatol. Sci. 53 (3) :182-191 (2009)

Background Reference 04

Turner, S.T., et al. Hypertension 52 (2) :359-365 (2008)

Other Product Names

Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2