API5 Antibody
Product Specifications
Background
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
NCBI Gene ID
8539
Swiss Prot
Q9BZZ5
Accession Number
Q9BZZ5
Host
Rabbit
Reactivity
Human
Immunogen
This API5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-510 amino acids from the C-terminal region of human API5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=60-149
Calculated Molecular Weight
59 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
API5
NCBI Official Name
Apoptosis inhibitor 5
NCBI Organism
Homo sapiens
Background Reference 01
Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) :
Background Reference 02
Ren, K., et al. Pathol. Oncol. Res. 16 (2) :229-237 (2010)
Background Reference 03
Need, A.C., et al. Hum. Mol. Genet. 18 (23) :4650-4661 (2009)
Background Reference 04
Rigou, P., et al. EMBO J. 28 (11) :1576-1588 (2009)
Other Product Names
Apoptosis inhibitor 5, API-5, Antiapoptosis clone 11 protein, AAC-11, Cell migration-inducing gene 8 protein, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL, API5
Tested Applications
WB
Protein ID
353526346
Physical Properties
Liquid
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