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MCF2L Antibody

Product Specifications

Background

Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity) . Isoform 5 activates CDC42.

NCBI Gene ID

23263

Swiss Prot

O15068

Accession Number

O15068

Host

Rabbit

Reactivity

Human

Immunogen

This MCF2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1075 amino acids from the C-terminal region of human MCF2L.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-130

Calculated Molecular Weight

128 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MCF2L

NCBI Official Name

Guanine nucleotide exchange factor DBS

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Takefuji, M., et al. J. Hum. Genet. 55 (1) :42-49 (2010)

Background Reference 03

Ieguchi, K., et al. J. Biol. Chem. 282 (32) :23296-23305 (2007)

Background Reference 04

Yang, Q., et al. BMC Med. Genet.SUPPL 1, S12 (2007) :

Other Product Names

Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like protein, MCF2L, KIAA0362

Tested Applications

WB

Physical Properties

Liquid

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