KATNA1 Antibody

Product Specifications

Background

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1) . The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. [provided by RefSeq].

NCBI Gene ID

11104

Swiss Prot

O75449

Accession Number

O75449

Host

Rabbit

Reactivity

Human

Immunogen

This KATNA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-85 amino acids from the N-terminal region of human KATNA1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

56 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KATNA1

NCBI Official Name

Katanin p60 ATPase-containing subunit A1 {ECO:0000255|HAMAP-Rule:MF_03023}

NCBI Organism

Homo sapiens

Background Reference 01

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 02

Iwaya, N., et al. J. Biol. Chem. 285 (22) :16822-16829 (2010)

Background Reference 03

Sudo, H., et al. Hum. Mol. Genet. 17 (16) :2524-2540 (2008)

Background Reference 04

Mungall, A.J., et al. Nature 425 (6960) :805-811 (2003)

Other Product Names

Katanin p60 ATPase-containing subunit A1 {ECO:0000255|HAMAP-Rule:MF_03023}, Katanin p60 subunit A1 {ECO:0000255|HAMAP-Rule:MF_03023}, 3643 {ECO:0000255|HAMAP-Rule:MF_03023}, p60 katanin {ECO:0000255|HAMAP-Rule:MF_03023}, KATNA1 {ECO:0000255|HAMAP-Rule:MF_03023}