CLN8 Antibody
Product Specifications
Background
This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL) . Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.
NCBI Gene ID
2055
Swiss Prot
Q9UBY8
Accession Number
Q9UBY8
Host
Rabbit
Reactivity
Human
Immunogen
This CLN8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-280 amino acids from the C-terminal region of human CLN8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=60-084
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CLN8
NCBI Official Name
Protein CLN8
NCBI Organism
Homo sapiens
Background Reference 01
Reinhardt, K., et al. Clin. Genet. 77 (1) :79-85 (2010)
Background Reference 02
Vantaggiato, C., et al. Hum. Mutat. 30 (7) :1104-1116 (2009)
Background Reference 03
Kousi, M., et al. Brain 132 (PT 3), 810-819 (2009) :
Background Reference 04
Striano, P., et al. Epilepsy Behav 10 (1) :187-191 (2007)
Other Product Names
Protein CLN8, CLN8, C8orf61
Tested Applications
WB
Protein ID
145559455
Physical Properties
Liquid
Curated Selection
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