TREML1 Antibody

Product Specifications

Background

TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876) -dependent manner (Allcock et al., 2003 [PubMed 12645956]; Barrow et al., 2004 [PubMed 15128762]) .[supplied by OMIM].

NCBI Gene ID

340205

Swiss Prot

Q86YW5

Accession Number

Q86YW5

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This TREML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-241 amino acids from the C-terminal region of human TREML1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TREML1

NCBI Official Name

Trem-like transcript 1 protein

NCBI Organism

Homo sapiens

Background Reference 01

Morales, J., et al. Blood Coagul. Fibrinolysis 21 (3) :229-236 (2010)

Background Reference 02

Washington, A.V., et al. J. Clin. Invest. 119 (6) :1489-1501 (2009)

Background Reference 03

Ford, J.W., et al. Curr. Opin. Immunol. 21 (1) :38-46 (2009)

Background Reference 04

Nurden, A.T., et al. Thromb. Haemost. 100 (1) :45-51 (2008)

Other Product Names

Trem-like transcript 1 protein, TLT-1, Triggering receptor expressed on myeloid cells-like protein 1, TREML1, TLT1

Tested Applications

Protein ID

116256098

Physical Properties

Liquid

Curated Selection

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