MRPL40 Antibody
Product Specifications
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.
NCBI Gene ID
64976
Swiss Prot
Q9NQ50
Accession Number
Q9NQ50
Host
Rabbit
Reactivity
Human
Immunogen
This MRPL40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human MRPL40.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=60-027
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MRPL40
NCBI Official Name
39S ribosomal protein L40, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Collins, J.E., et al. Genome Biol. (10), R84 (2004) :
Background Reference 02
Zhang, Z., et al. Genomics 81 (5) :468-480 (2003)
Background Reference 03
Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :
Background Reference 04
Hildebrandt, T., et al. Anticancer Res. 19 (1A), 525-530 (1999) :
Other Product Names
39S ribosomal protein L40, mitochondrial, L40mt, MRP-L40, Nuclear localization signal-containing protein deleted in velocardiofacial syndrome, Up-regulated in metastasis, MRPL40, NLVCF, URIM
Tested Applications
WB
Protein ID
21263795
Physical Properties
Liquid
Curated Selection
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