EGLN1 Antibody
Product Specifications
Background
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3) .
NCBI Gene ID
54583
Swiss Prot
Q9GZT9
Accession Number
Q9GZT9
Host
Rabbit
Reactivity
Human
Immunogen
This EGLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the C-terminal region of human EGLN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=60-009
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
EGLN1
NCBI Official Name
Egl nine homolog 1
NCBI Organism
Homo sapiens
Background Reference 01
Aggarwal, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (44) :18961-18966 (2010)
Background Reference 02
Vogel, S., et al. J. Biol. Chem. 285 (44) :33756-33763 (2010)
Background Reference 03
Simonson, T.S., et al. Science 329 (5987) :72-75 (2010)
Background Reference 04
Thoms, B.L., et al. J. Biol. Chem. 285 (27) :20472-20480 (2010)
Other Product Names
HGNC:1232
Tested Applications
WB
Protein ID
32129514
Physical Properties
Liquid
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