IL22RA2 Antibody

Product Specifications

Background

The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

NCBI Gene ID

116379

Swiss Prot

Q969J5

Accession Number

Q969J5

Host

Rabbit

Reactivity

Human

Immunogen

This IL22RA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-42 amino acids from the N-terminal region of human IL22RA2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

31 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

IL22RA2

NCBI Official Name

Interleukin-22 receptor subunit alpha-2

NCBI Organism

Homo sapiens

Background Reference 01

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Background Reference 02

Kingo, K., et al. J. Dermatol. Sci. 57 (1) :71-73 (2010)

Background Reference 03

Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

Background Reference 04

Endam, L.M., et al. Otolaryngol Head Neck Surg 140 (5) :741-747 (2009)

Other Product Names

Interleukin-22 receptor subunit alpha-2, IL-22 receptor subunit alpha-2, IL-22R-alpha-2, IL-22RA2, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, CRF2-10, Cytokine receptor family type 2, soluble 1, CRF2-S1, Interleukin-22-binding protein, IL-22BP, IL22BP, ZcytoR16, IL22RA2