GCNT2 Antibody

Product Specifications

Background

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.

NCBI Gene ID

2651

Swiss Prot

Q8N0V5

Accession Number

Q8N0V5

Host

Rabbit

Reactivity

Human

Immunogen

This GCNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-240 amino acids from the Central region of human GCNT2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GCNT2

NCBI Official Name

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A

NCBI Organism

Homo sapiens

Background Reference 01

Twu, Y.C., et al. Blood 110 (13) :4526-4534 (2007)

Background Reference 02

Wang, L., et al. Biochem. Biophys. Res. Commun. 331 (4) :958-963 (2005)

Background Reference 03

Pras, E., et al. Invest. Ophthalmol. Vis. Sci. 45 (6) :1940-1945 (2004)

Background Reference 04

Inaba, N., et al. Blood 101 (7) :2870-2876 (2003)

Other Product Names

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A, N-acetylglucosaminyltransferase, I-branching enzyme, IGNT, GCNT2, GCNT5, II, NACGT1