EXOSC1 Antibody

Product Specifications

Background

This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly (A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.

NCBI Gene ID

51013

Swiss Prot

Q9Y3B2

Accession Number

Q9Y3B2

Host

Rabbit

Reactivity

Human

Immunogen

This EXOSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids from the C-terminal region of human EXOSC1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

21 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

EXOSC1

NCBI Official Name

Exosome complex component CSL4

NCBI Organism

Homo sapiens

Background Reference 01

Andersen, J.S., et al. Nature 433 (7021) :77-83 (2005)

Background Reference 02

Lehner, B., et al. Genome Res. 14 (7) :1315-1323 (2004)

Background Reference 03

Deloukas, P., et al. Nature 429 (6990) :375-381 (2004)

Background Reference 04

Raijmakers, R., et al. J. Mol. Biol. 323 (4) :653-663 (2002)

Other Product Names

Exosome complex component CSL4, Exosome component 1, EXOSC1, CSL4

Tested Applications

Protein ID

14285410

Physical Properties

Liquid

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