VDR Antibody

Product Specifications

Background

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

NCBI Gene ID

7421

Swiss Prot

P11473

Accession Number

P11473

Host

Rabbit

Reactivity

Human

Immunogen

This VDR antibody is generated from rabbits immunized with a recombinant protein of human VDR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

VDR

NCBI Official Name

Vitamin D3 receptor

NCBI Organism

Homo sapiens

Background Reference 01

An, B.S., et al. Mol. Cell. Biol. 30 (20) :4890-4900 (2010)

Background Reference 02

Elnenaei, M.O., et al. Br. J. Nutr., 1-8 (2010) In press :

Background Reference 03

Forghani, N., et al. J. Pediatr. Endocrinol. Metab. 23 (8) :843-850 (2010)

Background Reference 04

Alvarez-Nava, F., et al. J. Pediatr. Endocrinol. Metab. 23 (8) :773-782 (2010)

Other Product Names

Vitamin D3 receptor, VDR,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1

Tested Applications

Protein ID

137617

Physical Properties

Liquid

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