SEPSECS Antibody
Product Specifications
Background
The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA (sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA (sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA (sec) . SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA (sec) to selenocysteinyl-tRNA (sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]) .
NCBI Gene ID
51091
Swiss Prot
Q9HD40
Accession Number
Q9HD40
Host
Rabbit
Reactivity
Human
Immunogen
This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=59-861
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SEPSECS
NCBI Official Name
O-phosphoseryl-tRNA (Sec) selenium transferase
NCBI Organism
Homo sapiens
Background Reference 01
Agamy, O., et al. Am. J. Hum. Genet. 87 (4) :538-544 (2010)
Background Reference 02
Hart, K., et al. Lung Cancer (2010) In press :
Background Reference 03
Volkmann, M., et al. J. Autoimmun. 34 (1) :59-65 (2010)
Background Reference 04
Palioura, S., et al. Science 325 (5938) :321-325 (2009)
Other Product Names
O-phosphoseryl-tRNA (Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA (Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA (Ser/Sec) -associated antigenic protein, SEPSECS, TRNP48
Tested Applications
WB
Protein ID
62287911
Physical Properties
Liquid
Curated Selection
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