TRHR Antibody

Product Specifications

Background

Thyrotropin-releasing hormone (TRH; MIM 275120), a small neuropeptide, is widely distributed throughout the central and peripheral nervous system as well as in extraneural tissues. The peptide is synthesized in the hypothalamus and transported by the portal vascular system to the anterior pituitary where it acts on thyrotropic and lactotropic cells to promote secretion of TSH and prolactin, respectively. Thyrotropin-releasing hormone receptor is a G protein-coupled receptor that activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon the binding of TRH. The TRHR gene is expressed in the thyrotrope cells of the anterior pituitary.

NCBI Gene ID

7201

Swiss Prot

P34981

Accession Number

P34981

Host

Rabbit

Reactivity

Human

Immunogen

This TRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-238 amino acids from the Central region of human TRHR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRHR

NCBI Official Name

Thyrotropin-releasing hormone receptor

NCBI Organism

Homo sapiens

Background Reference 01

Gehret, A.U., et al. Biochem. J. 428 (2) :235-245 (2010)

Background Reference 02

Gehret, A.U., et al. Mol. Pharmacol. 77 (2) :288-297 (2010)

Background Reference 03

Zhu, C.C., et al. J. Biol. Chem. 277 (31) :28228-28237 (2002)

Background Reference 04

Matre, V., et al. J. Neurochem. 72 (1) :40-50 (1999)

Other Product Names

Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor, TRHR

Tested Applications

Protein ID

464921

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GTR15371409 1 Vial

Lentiviral human RNF13 sgRNA gene knockout kit - Lentiviral human RNF13 sgRNA gene knockout kit (25)

Ask

View Details

MBS6319486-01 0.2 mL

MC5R, CT (MC5R, Melanocortin receptor 5, MC-2) (APC)

Ask

View Details

MBS6319486-02 5x 0.2 mL

MC5R, CT (MC5R, Melanocortin receptor 5, MC-2) (APC)

Ask

View Details

A67300-50UG 50 µg

HCFC1R1 Antibody, HRP conjugated

Ask

View Details

SS03000-01 0.5 g

Non-Functionalized Silica Microspheres - 0.50µm

Ask

View Details

SS03000-02 1.0 g

Non-Functionalized Silica Microspheres - 0.50µm

Ask

View Details