OSTM1 Antibody

Product Specifications

Background

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.

NCBI Gene ID

28962

Swiss Prot

Q86WC4

Accession Number

Q86WC4

Host

Rabbit

Reactivity

Human

Immunogen

This OSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-321 amino acids from the C-terminal region of human OSTM1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

OSTM1

NCBI Official Name

Osteopetrosis-associated transmembrane protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Yerges, L.M., et al. J. Bone Miner. Res. 24 (12) :2039-2049 (2009)

Background Reference 02

Mazzolari, E., et al. Am. J. Hematol. 84 (8) :473-479 (2009)

Background Reference 03

Vieira, A.R., et al. Genet. Med. 10 (9) :668-674 (2008)

Background Reference 04

Feigin, M.E., et al. Cell. Signal. 20 (5) :949-957 (2008)

Other Product Names

Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit, OSTM1, GL

Tested Applications

Protein ID

51316434

Physical Properties

Liquid

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