GNPTG Antibody
Product Specifications
Background
This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.
NCBI Gene ID
84572
Swiss Prot
Q9UJJ9
Accession Number
Q9UJJ9
Host
Rabbit
Reactivity
Human
Immunogen
This GNPTG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-296 amino acids from the C-terminal region of human GNPTG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GNPTG
NCBI Official Name
N-acetylglucosamine-1-phosphotransferase subunit gamma
NCBI Organism
Homo sapiens
Background Reference 01
Kang, C., et al. N. Engl. J. Med. 362 (8) :677-685 (2010)
Background Reference 02
Qian, Y., et al. J. Biol. Chem. 285 (5) :3360-3370 (2010)
Background Reference 03
Pohl, S., et al. Am. J. Med. Genet.152A (1), 124-132 (2010) :
Background Reference 04
Encarnacao, M., et al. Clin. Genet. 76 (1) :76-84 (2009)
Other Product Names
N-acetylglucosamine-1-phosphotransferase subunit gamma, GlcNAc-1-phosphotransferase subunit gamma, UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma, GNPTG, C16orf27, GNPTAG
Tested Applications
WB
Physical Properties
Liquid
Frequently Asked Questions
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