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GNPTG Antibody

Product Specifications

Background

This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.

NCBI Gene ID

84572

Swiss Prot

Q9UJJ9

Accession Number

Q9UJJ9

Host

Rabbit

Reactivity

Human

Immunogen

This GNPTG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-296 amino acids from the C-terminal region of human GNPTG.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-732

Calculated Molecular Weight

34 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GNPTG

NCBI Official Name

N-acetylglucosamine-1-phosphotransferase subunit gamma

NCBI Organism

Homo sapiens

Background Reference 01

Kang, C., et al. N. Engl. J. Med. 362 (8) :677-685 (2010)

Background Reference 02

Qian, Y., et al. J. Biol. Chem. 285 (5) :3360-3370 (2010)

Background Reference 03

Pohl, S., et al. Am. J. Med. Genet.152A (1), 124-132 (2010) :

Background Reference 04

Encarnacao, M., et al. Clin. Genet. 76 (1) :76-84 (2009)

Other Product Names

N-acetylglucosamine-1-phosphotransferase subunit gamma, GlcNAc-1-phosphotransferase subunit gamma, UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma, GNPTG, C16orf27, GNPTAG

Tested Applications

WB

Physical Properties

Liquid

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