Sik1 Antibody

Product Specifications

Background

Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.

NCBI Gene ID

17691

Swiss Prot

Q60670

Accession Number

Q60670

Host

Rabbit

Reactivity

Human

Immunogen

This Sik1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 573-600 amino acids from the C-terminal region of mouse Sik1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

85 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Sik1

NCBI Official Name

Serine/threonine-protein kinase SIK1

NCBI Organism

Mus musculus

Background Reference 01

Romito, A., et al. PLoS ONE (2), E9029 (2010) :

Background Reference 02

Takemori, H., et al. Endocr. J. 56 (1) :121-130 (2009)

Background Reference 03

Berdeaux, R., et al. Nat. Med. 13 (5) :597-603 (2007)

Background Reference 04

Katoh, Y., et al. FEBS J. 273 (12) :2730-2748 (2006)

Other Product Names

Serine/threonine-protein kinase SIK1, HRT-20, Myocardial SNF1-like kinase, Salt-inducible kinase 1, SIK-1, Serine/threonine-protein kinase SNF1-like kinase 1, Serine/threonine-protein kinase SNF1LK, Sik1, Msk, Sik, Snf1lk