PLEKHA1 Antibody

Product Specifications

Background

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.

NCBI Gene ID

59338

Swiss Prot

Q9HB21

Accession Number

Q9HB21

Host

Rabbit

Reactivity

Human

Immunogen

This PLEKHA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human PLEKHA1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PLEKHA1

NCBI Official Name

Pleckstrin homology domain-containing family A member 1

NCBI Organism

Homo sapiens

Background Reference 01

Deangelis, M.M., et al. Ophthalmology 115 (7) :1209-1215 (2008)

Background Reference 02

Manna, D., et al. J. Biol. Chem. 282 (44) :32093-32105 (2007)

Background Reference 03

Kanda, A., et al. Proc. Natl. Acad. Sci. U.S.A. 104 (41) :16227-16232 (2007)

Background Reference 04

Leveziel, N., et al. Mol. Vis. 13, 2153-2159 (2007) :

Other Product Names

Pleckstrin homology domain-containing family A member 1, PH domain-containing family A member 1, Tandem PH domain-containing protein 1, TAPP-1, PLEKHA1, TAPP1