What is the catalog number for NFKBp65 Antibody?

The catalog number for NFKBp65 Antibody is 59-721.

What sizes are available for NFKBp65 Antibody?

NFKBp65 Antibody is available in the following size(s): 400 µL.

Is NFKBp65 Antibody in stock?

NFKBp65 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

NFKBp65 Antibody

Product Specifications

Background

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1) /p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine) .

NCBI Gene ID

5970

Swiss Prot

Q04206

Accession Number

Q04206

Host

Rabbit

Reactivity

Human

Immunogen

This NFKBp65 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 517-539 amino acids from the C-terminal region of human NFKBp65.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

RELA

NCBI Official Name

Transcription factor p65

NCBI Organism

Homo sapiens

Background Reference 01

Pan, W.W., et al. J. Biol. Chem. 285 (45) :34348-34354 (2010)

Background Reference 02

Tago, K., et al. J. Biol. Chem. 285 (40) :30622-30633 (2010)

Background Reference 03

Park, J.S., et al. Oncol. Rep. 24 (3) :709-714 (2010)

Background Reference 04

Yu, Z.H., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26 (7) :650-652 (2010)

Other Product Names

Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3

Tested Applications

WB, IF

Protein ID

62906901

Physical Properties

Liquid

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