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RGS19 Antibody

Product Specifications

Background

RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole) .

NCBI Gene ID

10287

Swiss Prot

P49795

Accession Number

P49795

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This RGS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-156 amino acids from human RGS19.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-715

Calculated Molecular Weight

25 kDa

Fragment

Rabbit Ig

Symbol

RGS19

NCBI Official Name

Regulator of G-protein signaling 19

NCBI Organism

Homo sapiens

Background Reference 01

Baehrecke EH. Nat Rev Mol Cell Biol. 6 (6) :505-10. (2005)

Background Reference 02

Lum JJ, et al. Nat Rev Mol Cell Biol. 6 (6) :439-48. (2005)

Background Reference 03

Greenberg JT. Dev Cell. 8 (6) :799-801. (2005)

Background Reference 04

Levine B. Cell. 120 (2) :159-62. (2005)

Other Product Names

Regulator of G-protein signaling 19, RGS19, G-alpha-interacting protein, GAIP, RGS19, GAIP, GNAI3IP

Tested Applications

WB, IHC-P

Protein ID

1730186

Physical Properties

Liquid

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