ALG11 Antibody
Product Specifications
Background
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP) . This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19.
NCBI Gene ID
440138
Swiss Prot
Q2TAA5
Accession Number
Q2TAA5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ALG11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-468 amino acids from the C-terminal region of human ALG11.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=59-672
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ALG11
NCBI Official Name
GDP-Man:Man (3) GlcNAc (2) -PP-Dol alpha-1,2-mannosyltransferase
NCBI Organism
Homo sapiens
Background Reference 01
Rind, N., et al. Hum. Mol. Genet. 19 (8) :1413-1424 (2010)
Background Reference 02
Rohozinski, J., et al. Biol. Reprod. 74 (4) :644-651 (2006)
Other Product Names
GDP-Man:Man (3) GlcNAc (2) -PP-Dol alpha-1,2-mannosyltransferase, Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase, ALG11, GT8
Tested Applications
WB
Protein ID
156631015
Physical Properties
Liquid
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