GTF2IRD1 Antibody

Product Specifications

Background

The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq].

NCBI Gene ID

9569

Swiss Prot

Q9UHL9

Accession Number

Q9UHL9

Host

Rabbit

Reactivity

Human

Immunogen

This GTF2IRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the N-terminal region of human GTF2IRD1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

106 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GTF2IRD1

NCBI Official Name

General transcription factor II-I repeat domain-containing protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Antonell, A., et al. J. Med. Genet. 47 (5) :312-320 (2010)

Background Reference 02

Palmer, S.J., et al. J. Biol. Chem. 285 (7) :4715-4724 (2010)

Background Reference 03

Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

Background Reference 04

Dai, L., et al. Am. J. Med. Genet.149A (3), 302-314 (2009) :

Other Product Names

General transcription factor II-I repeat domain-containing protein 1, GTF2I repeat domain-containing protein 1, General transcription factor III, MusTRD1/BEN, Muscle TFII-I repeat domain-containing protein 1, Slow-muscle-fiber enhancer-binding protein, USE B1-binding protein, Williams-Beuren syndrome chromosomal region 11 protein, Williams-Beuren syndrome chromosomal region 12 protein, GTF2IRD1