GTF2I Antibody

Product Specifications

Background

This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.

NCBI Gene ID

2969

Swiss Prot

P78347

Accession Number

P78347

Host

Rabbit

Reactivity

Human

Immunogen

This GTF2I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-310 amino acids from the N-terminal region of human GTF2I.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

112 kDa

Fragment

Rabbit Ig

Symbol

GTF2I

NCBI Official Name

General transcription factor II-I

NCBI Organism

Homo sapiens

Background Reference 01

Antonell, A., et al. J. Med. Genet. 47 (5) :312-320 (2010)

Background Reference 02

Lazebnik, M.B., et al. J. Biol. Chem. 284 (52) :36234-36239 (2009)

Background Reference 03

Sacristan, C., et al. Eur. J. Immunol. 39 (9) :2584-2595 (2009)

Background Reference 04

Makeyev, A.V., et al. Gene 433 (1-2), 16-25 (2009) :

Other Product Names

General transcription factor II-I, GTFII-I, TFII-I, Bruton tyrosine kinase-associated protein 135, BAP-135, BTK-associated protein 135, SRF-Phox1-interacting protein, SPIN, Williams-Beuren syndrome chromosomal region 6 protein, GTF2I, BAP135, WBSCR6