ITGB2 Antibody

Product Specifications

Background

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1) . Two transcript variants encoding the same protein have been identified for this gene.

NCBI Gene ID

3689

Swiss Prot

P05107

Accession Number

P05107

Host

Rabbit

Reactivity

Human

Immunogen

This ITGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-300 amino acids from the N-terminal region of human ITGB2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

85 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ITGB2

NCBI Official Name

Integrin beta-2

NCBI Organism

Homo sapiens

Background Reference 01

Gjelstrup, L.C., et al. J. Immunol. 185 (7) :4154-4168 (2010)

Background Reference 02

Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

Background Reference 03

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 04

Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (33) :14727-14732 (2010)

Other Product Names

Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7

Tested Applications

Protein ID

124056465

Physical Properties

Liquid

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