MYH9 Antibody

Product Specifications

Background

This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness.

NCBI Gene ID

4627

Swiss Prot

P35579

Accession Number

P35579

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MYH9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1840-1867 amino acids from the C-terminal region of human MYH9.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

227 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:2000

Symbol

MYH9

NCBI Official Name

Myosin-9

NCBI Organism

Homo sapiens

Background Reference 01

Arii, J., et al. Nature 467 (7317) :859-862 (2010)

Background Reference 02

Genovese, G., et al. Kidney Int. 78 (7) :698-704 (2010)

Background Reference 03

Tzur, S., et al. Hum. Genet. 128 (3) :345-350 (2010)

Background Reference 04

Bostrom, M.A., et al. Hum. Genet. 128 (2) :195-204 (2010)

Other Product Names

Myosin-9, Cellular myosin heavy chain, type A, Myosin heavy chain 9, Myosin heavy chain, non-muscle IIa, Non-muscle myosin heavy chain A, NMMHC-A, Non-muscle myosin heavy chain IIa, NMMHC II-a, NMMHC-IIA, MYH9