NDST4 Antibody

Product Specifications

Background

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity) .

NCBI Gene ID

64579

Swiss Prot

Q9H3R1

Accession Number

Q9H3R1

Host

Rabbit

Reactivity

Human

Immunogen

This NDST4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-212 amino acids from the N-terminal region of human NDST4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

101 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NDST4

NCBI Official Name

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Kalsi, G., et al. Hum. Mol. Genet. 19 (12) :2497-2506 (2010)

Background Reference 03

Treutlein, J., et al. Arch. Gen. Psychiatry 66 (7) :773-784 (2009)

Background Reference 04

Aikawa, J., et al. J. Biol. Chem. 276 (8) :5876-5882 (2001)

Other Product Names

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4, Glucosaminyl N-deacetylase/N-sulfotransferase 4, NDST-4, N-heparan sulfate sulfotransferase 4, N-HSST 4, Heparan sulfate N-deacetylase 4, 3---, Heparan sulfate N-sulfotransferase 4, 282-, NDST4, HSST4