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MRGBP Antibody

Product Specifications

Background

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

NCBI Gene ID

55257

Swiss Prot

Q9NV56

Accession Number

Q9NV56

Host

Rabbit

Reactivity

Human

Immunogen

This MRGBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the Central region of human MRGBP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MRGBP

NCBI Official Name

MRG/MORF4L-binding protein

NCBI Organism

Homo sapiens

Background Reference 01

Yamaguchi, K., et al. Br. J. Cancer 102 (2) :325-331 (2010)

Background Reference 02

Cai, Y., et al. J. Biol. Chem. 280 (14) :13665-13670 (2005)

Background Reference 03

Cai, Y., et al. J. Biol. Chem. 278 (44) :42733-42736 (2003)

Background Reference 04

Deloukas, P., et al. Nature 414 (6866) :865-871 (2001)

Other Product Names

MRG/MORF4L-binding protein, MRG-binding protein, Up-regulated in colon cancer 4, Urcc4, MRGBP, C20orf20

Tested Applications

WB

Protein ID

28201787

Physical Properties

Liquid

Frequently Asked Questions

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