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GNMT Antibody

Product Specifications

Background

The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia) .

NCBI Gene ID

27232

Swiss Prot

Q14749

Accession Number

Q14749

Host

Rabbit

Reactivity

Human

Immunogen

This GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the Central region of human GNMT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig, Rabbit

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GNMT

NCBI Official Name

Glycine N-methyltransferase

NCBI Organism

Homo sapiens

Background Reference 01

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 02

Lee, C.M., et al. Gene 443 (1-2), 151-157 (2009) :

Background Reference 03

Boyles, A.L., et al. Genet. Epidemiol. 33 (3) :247-255 (2009)

Background Reference 04

Yen, C.H., et al. Toxicol. Appl. Pharmacol. 235 (3) :296-304 (2009)

Other Product Names

Glycine N-methyltransferase, GNMT

Tested Applications

WB

Protein ID

12644416

Physical Properties

Liquid

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