FZD7 Antibody

Product Specifications

Background

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

NCBI Gene ID

8324

Swiss Prot

O75084

Accession Number

O75084

Host

Rabbit

Reactivity

Human

Immunogen

This FZD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-229 amino acids from the Central region of human FZD7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FZD7

NCBI Official Name

Frizzled-7

NCBI Organism

Homo sapiens

Background Reference 01

Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

Background Reference 02

Vincan, E., et al. Dev. Dyn. 239 (1) :311-317 (2010)

Background Reference 03

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 04

Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)

Other Product Names

Frizzled-7, Fz-7, hFz7, FzE3, FZD7

Tested Applications

Physical Properties

Liquid

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