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DMGDH Antibody

Product Specifications

Background

This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.

NCBI Gene ID

29958

Swiss Prot

Q9UI17

Accession Number

Q9UI17

Host

Rabbit

Reactivity

Human

Immunogen

This DMGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836-864 amino acids from the C-terminal region of human DMGDH.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-586

Calculated Molecular Weight

97 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

DMGDH

NCBI Official Name

Dimethylglycine dehydrogenase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Mostowska, A., et al. Eur. J. Oral Sci. 118 (4) :325-332 (2010)

Background Reference 02

Bailey, S.D., et al. Diabetes Care (2010) In press :

Background Reference 03

Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

Background Reference 04

Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

Other Product Names

Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH, DMGDH

Tested Applications

WB

Protein ID

296434575

Physical Properties

Liquid

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