PDCD10 Antibody

Product Specifications

Background

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].

NCBI Gene ID

11235

Swiss Prot

Q9BUL8

Accession Number

Q9BUL8

Host

Rabbit

Reactivity

Human

Immunogen

This PDCD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human PDCD10.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Zebrafish, Chicken, Mouse, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

25 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDCD10

NCBI Official Name

Programmed cell death protein 10

NCBI Organism

Homo sapiens

Background Reference 01

Lauenborg, B., et al. APMIS 118 (10) :719-728 (2010)

Background Reference 02

Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

Background Reference 03

Ding, J., et al. Biochem. Biophys. Res. Commun. 399 (4) :587-592 (2010)

Background Reference 04

Zheng, X., et al. J. Clin. Invest. 120 (8) :2795-2804 (2010)

Other Product Names

Programmed cell death protein 10, Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15, PDCD10, CCM3, TFAR15

Tested Applications

Protein ID

74733232

Physical Properties

Liquid

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