FBXL12 Antibody

Product Specifications

Background

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]) .[supplied by OMIM].

NCBI Gene ID

54850

Swiss Prot

Q9NXK8

Accession Number

Q9NXK8

Host

Rabbit

Reactivity

Human

Immunogen

This FBXL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-303 amino acids from the C-terminal region of human FBXL12.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FBXL12

NCBI Official Name

F-box/LRR-repeat protein 12

NCBI Organism

Homo sapiens

Background Reference 01

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Background Reference 02

Barrios-Rodiles, M., et al. Science 307 (5715) :1621-1625 (2005)

Background Reference 03

Jin, J., et al. Genes Dev. 18 (21) :2573-2580 (2004)

Background Reference 04

Winston, J.T., et al. Curr. Biol. 9 (20) :1180-1182 (1999)

Other Product Names

F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12, FBXL12, FBL12

Tested Applications

Protein ID

38257780

Physical Properties

Liquid

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