DR1 Antibody

Product Specifications

Background

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

NCBI Gene ID

1810

Swiss Prot

Q01658

Accession Number

Q01658

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This DR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human DR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

19 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

DR1

NCBI Official Name

Protein Dr1

NCBI Organism

Homo sapiens

Background Reference 01

Corneveaux, J.J., et al. Hum. Mol. Genet. 19 (16) :3295-3301 (2010)

Background Reference 02

Kantidakis, T., et al. Nucleic Acids Res. 38 (4) :1228-1239 (2010)

Background Reference 03

Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :

Background Reference 04

Kahle, J., et al. J. Biol. Chem. 284 (14) :9382-9393 (2009)

Other Product Names

Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1

Tested Applications

Protein ID

401162

Physical Properties

Liquid

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

abx102120-01 100 µL

Creatine Kinase B-Type (CKB) Antibody

Ask

View Details

abx102120-02 200 µL

Creatine Kinase B-Type (CKB) Antibody

Ask

View Details

abx102120-03 1 mL

Creatine Kinase B-Type (CKB) Antibody

Ask

View Details

MBS2160309-01 96 Tests

Ribonucleotide Reductase M1 (RRM1) Magnetic Fluorescence Assay Kit

Ask

View Details

MBS2160309-02 5x 96 Tests

Ribonucleotide Reductase M1 (RRM1) Magnetic Fluorescence Assay Kit

Ask

View Details

MBS2160309-03 10x 96 Tests

Ribonucleotide Reductase M1 (RRM1) Magnetic Fluorescence Assay Kit

Ask

View Details