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HNRPLL Antibody

Product Specifications

Background

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]) .

NCBI Gene ID

92906

Swiss Prot

Q8WVV9

Accession Number

Q8WVV9

Host

Rabbit

Reactivity

Human

Immunogen

This HNRPLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 amino acids from the N-terminal region of human HNRPLL.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HNRNPLL

NCBI Official Name

Heterogeneous nuclear ribonucleoprotein L-like

NCBI Organism

Homo sapiens

Background Reference 01

Wu, Z., et al. J. Immunol. 185 (1) :231-238 (2010)

Background Reference 02

Topp, J.D., et al. RNA 14 (10) :2038-2049 (2008)

Background Reference 03

Oberdoerffer, S., et al. Science 321 (5889) :686-691 (2008)

Background Reference 04

Lim, J., et al. Cell 125 (4) :801-814 (2006)

Other Product Names

Heterogeneous nuclear ribonucleoprotein L-like, hnRNPLL, Stromal RNA-regulating factor, HNRNPLL, HNRPLL, SRRF

Tested Applications

WB

Protein ID

62286941

Physical Properties

Liquid

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