SRGAP1 Antibody
Product Specifications
Background
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
NCBI Gene ID
57522
Swiss Prot
Q7Z6B7
Accession Number
Q7Z6B7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SRGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 469-497 amino acids from the Central region of human SRGAP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
124 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SRGAP1
NCBI Official Name
SLIT-ROBO Rho GTPase-activating protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 02
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Background Reference 03
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 04
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Other Product Names
SLIT-ROBO Rho GTPase-activating protein 1, srGAP1, Rho GTPase-activating protein 13, SRGAP1, ARHGAP13, KIAA1304
Tested Applications
WB
Protein ID
48428624
Physical Properties
Liquid
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