SERPINI2 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

NCBI Gene ID

5276

Swiss Prot

O75830

Accession Number

O75830

Host

Rabbit

Reactivity

Human

Immunogen

This SERPINI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-401 amino acids from the C-terminal region of human SERPINI2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SERPINI2

NCBI Official Name

Serpin I2

NCBI Organism

Homo sapiens

Background Reference 01

Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

Background Reference 02

Lim, J., et al. Cell 125 (4) :801-814 (2006)

Background Reference 03

Chang, W.S., et al. Genes Chromosomes Cancer 29 (3) :240-255 (2000)

Background Reference 04

Xiao, G., et al. Proc. Natl. Acad. Sci. U.S.A. 96 (7) :3700-3705 (1999)

Other Product Names

Serpin I2, Myoepithelium-derived serine protease inhibitor, Pancpin, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI-14, SERPINI2, MEPI, PI14