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PACRG Antibody

Product Specifications

Background

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

135138

Swiss Prot

Q96M98

Accession Number

Q96M98

Host

Rabbit

Reactivity

Human

Immunogen

This PACRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human PACRG.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=59-356

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PACRG

NCBI Official Name

Parkin coregulated gene protein

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Wilson, G.R., et al. Fertil. Steril. 93 (7) :2262-2268 (2010)

Background Reference 03

Dagda, R.K., et al. J. Bioenerg. Biomembr. 41 (6) :473-479 (2009)

Background Reference 04

Velez, D.R., et al. Int. J. Tuberc. Lung Dis. 13 (9) :1068-1076 (2009)

Other Product Names

Parkin coregulated gene protein, Molecular chaperone/chaperonin-binding protein, PARK2 coregulated gene protein, PACRG, GLUP

Tested Applications

WB

Protein ID

77416872

Physical Properties

Liquid

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