RNF14 Antibody

Product Specifications

Background

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.

NCBI Gene ID

9604

Swiss Prot

Q9UBS8

Accession Number

Q9UBS8

Host

Rabbit

Reactivity

Human

Immunogen

This RNF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human RNF14.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RNF14

NCBI Official Name

E3 ubiquitin-protein ligase RNF14

NCBI Organism

Homo sapiens

Background Reference 01

Xu, K., et al. Cancer Cell 15 (4) :270-282 (2009)

Background Reference 02

Lan, K.C., et al. Fertil. Steril. 89 (5 SUPPL), 1397-1405 (2008) :

Background Reference 03

Kikuchi, H., et al. Carcinogenesis 28 (8) :1752-1758 (2007)

Background Reference 04

Yang, Z., et al. Endocrinology 148 (3) :1340-1349 (2007)

Other Product Names

E3 ubiquitin-protein ligase RNF14, 632-, Androgen receptor-associated protein 54, HFB30, RING finger protein 14, Triad2 protein, RNF14, ARA54

Tested Applications

Protein ID

17380293

Physical Properties

Liquid

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