RGL4 Antibody

Product Specifications

Background

Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL4 (ral guanine nucleotide dissociation stimulator-like 4), also known as Rgr, is a 473 amino acid protein that localizes to the cytoplasmic vesicle of cells. Belonging to the GEF family of proteins, RGL4 induces phosphorylation of ERKs, p38 and JNK kinases, and it increases the levels of GTP bound forms of Ral and Ras. Ras activation is crucial for the transforming activity of RGL4. Due to its similarity to Ral GDS, RGL4 may be implicated in carcinogenesis.

NCBI Gene ID

266747

Swiss Prot

Q8IZJ4

Accession Number

Q8IZJ4

Host

Rabbit

Reactivity

Human

Immunogen

This RGL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-125 amino acids from the N-terminal region of human RGL4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

52 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RGL4

NCBI Official Name

Ral-GDS-related protein

NCBI Organism

Homo sapiens

Background Reference 01

Hernandez-Munoz, I., et al. Cancer Res. 63 (14) :4188-4195 (2003)

Background Reference 02

Hernandez-Munoz, I., et al. Oncogene 19 (23) :2745-2757 (2000)

Background Reference 03

Dunham, I., et al. Nature 402 (6761) :489-495 (1999)

Background Reference 04

D'Adamo, D.R., et al. Oncogene 14 (11) :1295-1305 (1997)

Other Product Names

Ral-GDS-related protein, hRGR, Ral guanine nucleotide dissociation stimulator-like 4, RalGDS-like 4, RGL4, RGR

Tested Applications

Protein ID

34222891

Physical Properties

Liquid

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