PNPT1 Antibody

Product Specifications

Background

PNPT1 is a subunit of the exosome complex, which is involved in 3-prime-to-5-prime exoribonuclease activity for RNA processing and degradation (Raijmakers et al., 2002 [PubMed 12419256]) .

NCBI Gene ID

87178

Swiss Prot

Q8TCS8

Accession Number

Q8TCS8

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PNPT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-311 amino acids from the Central region of human PNPT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Immunology, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

86 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PNPT1

NCBI Official Name

Polyribonucleotide nucleotidyltransferase 1, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Wang, G., et al. Cell 142 (3) :456-467 (2010)

Background Reference 02

Das, S.K., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (26) :11948-11953 (2010)

Background Reference 03

Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :

Background Reference 04

O'Doherty, C., et al. Pharmacogenomics 10 (7) :1177-1186 (2009)

Other Product Names

Polyribonucleotide nucleotidyltransferase 1, mitochondrial, 3'-5' RNA exonuclease OLD35, PNPase old-35, Polynucleotide phosphorylase 1, PNPase 1, Polynucleotide phosphorylase-like protein, PNPT1, PNPASE